"Saul Krugman, Joan Giles and other researchers conduct hepatitis experiments on mentally disabled children at The Willowbrook State School. They intentionally infected subjects with the disease and observed its natural progression. The experiments were approved by the New York Department of Health."

Source: Research Ethics Timeline (1932-Present) by David B. Resnik, J.D., Ph.D.

http://www.niehs.nih.gov/research/resources/bioethics/timeline.cfm

NIEHS is the acronym for the National Institute of Environmental Health Sciences within the National Institutes of Health.