Well, as the manga has been going...many things can happen...but there's something that it kind of worried me...or maybe is far to happen...but...here it is as posted on the SasuHina FC at the Naruto Forums

The last manga chapter got many things to think about. And there's still something that doesn't fit yet:

If everything that Itachi said was true; then why their parents had two kids, knowing the 'fate' between brothers due to the circumstances of the clan? And still...why kill all them? It still doesn't have sense to kill everyone when there's more chance to pick other two brothers if the Sasuke/Itachi thing doesn't work.

And if Madara in the end is nothing to what he was when he got the Mangekyo...why Itachi insists to have it? He was defeated twice, by the First and Fourth Hokage...and still using the Kyuubi...

It seems like a waste of time.

Something's odd...and Itachi has the answer.

And this also brings back the Hyuuga issue:

Is said that the curse seal on the branch family was to prevent outsiders to steal the secrets of the eye, right? What if the outsider's that Neji explained at that moment were no other than the Uchiha? Maybe they have tried to steal the Byakugan eye...or that they have taken Hyuuga girls with that purpose? Because until now is all between the male Uchiha's...no mentioning the women of the clan.

And with Hinata at the rescue group, and for being from the main house and not having the curse seal...

Is there a chance for her to die for her eye? Being killed by either Itachi or Sasuke? Because I bet that someone from the team is going to die...like Kishimoto tends to do.

OKay, I want to hear you out ^^

If someone dies it's most likely going to be Itachi or Sasuke. I'm fairly certain that even if Sasuke dies, it's not going to be until the very end. Or at least until he meets up with Naruto again.

I'm not sure about the Hyuuga eyes, but it's an interesting concept. My SasuHina side says that it would be much easier to create a hybrid through mating. But would it work... implanting eyes? I'm not sure. I sort of wish the Hyuuga family had a little more relevance to the plot. Then we might be able to speculate something.

I'm not sure how all the pieces fit together (all my theories died when Itachi went crazy. I haven't had the heart to think up more). We'll find out sooner or later.